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<p>[QUOTE=&quot;Zohar444, post: 911120, member: 13450&quot;]Of the many attributes identified with the Habsburg dynasty it is the hereditary over-grown jaw (mandibular prognathism) that captures the most attention.It is clearly visible in many of the increasing natural portraits of the family from the Renaissance and after, and also is seen on coinage of the period. <i>(The coin of Leopold the “Hogmouth” shown above demonstrates the deformity.)</i> What we do seem to see from the surviving portraits is that the deformaty developed and increased with the age of the victim. Sometimes so serious as to inhibit talking or eating, and often linked to a lack of mental sharpness, the problem never interferred with hereditary succession. Well served by an efficient bureaucracy, the Habsburgs long endured despite increasing inattention to duty and only disappeared in Spain due to the king&#039;s failure to produce an heir. </p><p>&nbsp;</p><p><br /></p><p>There is no dispute that the genetic flaw entered the Habsurg family with Cymburga of Masowia early in the fifteenth century when she married Duke Ernst of Inner Austria. The European nobility had, by this time, already thoroughly intermarried and so the true sources of such genetic aberations is too often shrouded in mystery and complex ancestry. Cymburga carried genes from Portugese, Spanish, Austrian and Burgundian ancestors. Who, or what pairing, or which ancestors brought the deformity is beyond telling. Her eldest son, Friedrich III, the German Emperor, shows a strong but not mishapen chin. However, his son Maximillian had a serious jaw deformation that was made more prominant by his chunky visage. From him the jaw descended into both the Spanish and Austrian/German Royal lines for at least two centuries before being seemingly disappearing. We have no idea if it is gone forever or may reappear again with a new marriage that revivies the gene. </p><p>&nbsp;</p><p>Certainly the very high degree of intermarriage between the various branches of the Habsburgs greatly contributed to the prevalence of the problem <i>(The Spanish king Carlos II is pictured at the left)</i>. There were multiple marriages of uncles and nieces, first cousins (not to mention second, third or more distant), nephews and aunts and in the case of Philip II all three. That one crucial marriage was with Juana &quot;The Mad&quot;, who truly was unstable, only made the intermarriages more unfortunate for their offspring. Other known familial problems included stomach problems, asthma, gout, a tendency to dropsy (COPE), epilepsy, depression and a seeming weak resistence to syphilis (which might also have been spead through prenatal transmission). There are few studies on prognathism and its hereditary transmission, but one by Schulze and Weise led them to believe the deformity was an irregualrly dominant gene but with variable penetrance. They could not determine if it was actually the result of multiple gene aberations or of one alone. The likely conclusion for the Habsburgs is that the gene is still present but weak and recessive. We do know that exhibiting the genetic malformation was not sexually linked as we have portraits of female Habsburgs with the deformed jaw, although transmission was sexually linked and afflicted some 50% of the Habsburgs. Otherwise it remains a mystery of past history that troubles the Habsburgs no more.[/QUOTE]</p><p><br /></p>

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