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<p>[QUOTE="desertgem, post: 4412831, member: 15199"]Some groups may not want to read this but here is the conclusion most widely spread among Archeo-geneticists working with the mitochondrial-DNA,</p><p><br /></p><p>"Clearly, the role of the mitochondrial genome must be considered with respect to human genetic disease. The heterogeneity of the mitochondrial genome presents many unmet challenges to researchers. However, emerging technologies are likely to aid the discovery of underlying genetic mechanisms linking these powerhouses to neurodegenerative disease, cancer, diabetes, and aging."</p><p><br /></p><p>"Mitochondrial DNA plays important roles in other areas of genetics as well. For example, it has been used to address questions about how the widespread distribution of humans in the world today was established. Because mitochondria are passed exclusively through the maternal lineage and there is little recombination in the mitochondrial genome, variation in the mitochondrial genome (as well as in the Y chromosome in the case of paternal lineages) has been used to delineate how and when humans migrated and occupied the world.<span style="color: #ff0000"> Studying the mitochondrial genome in individuals from distinct geographic origins has made it possible to establish that the human populations of today are all derived from a small group of individuals that left Africa approximately 170,000 years ago" (Ingman <i>et al.</i>, 2000).</span></p><p><br /></p><p><a href="https://www.nature.com/scitable/topicpage/mtdna-and-mitochondrial-diseases-903/" target="_blank" class="externalLink ProxyLink" data-proxy-href="https://www.nature.com/scitable/topicpage/mtdna-and-mitochondrial-diseases-903/" rel="nofollow">https://www.nature.com/scitable/topicpage/mtdna-and-mitochondrial-diseases-903/</a></p><p><br /></p><p>Jim[/QUOTE]</p><p><br /></p>
[QUOTE="desertgem, post: 4412831, member: 15199"]Some groups may not want to read this but here is the conclusion most widely spread among Archeo-geneticists working with the mitochondrial-DNA, "Clearly, the role of the mitochondrial genome must be considered with respect to human genetic disease. The heterogeneity of the mitochondrial genome presents many unmet challenges to researchers. However, emerging technologies are likely to aid the discovery of underlying genetic mechanisms linking these powerhouses to neurodegenerative disease, cancer, diabetes, and aging." "Mitochondrial DNA plays important roles in other areas of genetics as well. For example, it has been used to address questions about how the widespread distribution of humans in the world today was established. Because mitochondria are passed exclusively through the maternal lineage and there is little recombination in the mitochondrial genome, variation in the mitochondrial genome (as well as in the Y chromosome in the case of paternal lineages) has been used to delineate how and when humans migrated and occupied the world.[COLOR=#ff0000] Studying the mitochondrial genome in individuals from distinct geographic origins has made it possible to establish that the human populations of today are all derived from a small group of individuals that left Africa approximately 170,000 years ago" (Ingman [I]et al.[/I], 2000).[/COLOR] [URL]https://www.nature.com/scitable/topicpage/mtdna-and-mitochondrial-diseases-903/[/URL] Jim[/QUOTE]
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