If it were me, I'd open it. I'd rather open it and find out there's only one in there than to sell it intact on eBay and then see someone pop up on this website talking about how they just bought a roll full of extra leaf Wisconsin quarters on eBay. You'd be kicking yourself for awhile if that happened.
Actually, I would just hold on to it for a while and do what I want. I have a roll of Homestead Quarters I got from the bank with a small DDO on the reverse. I wonder if those will ever be collectible.
I certainly cannot say for sure, but can tell you that once demand for certain lesser varieties cool down, they often die. In 09, due to the popularity of the Lincoln bicentennial cent varieties and the ease of acquiring one type locally, I ended up getting my hands on quite a number of different DDRs and did fairly well with them.... as long as they were popular. Since then I've had tubes of certain varieties, ones Wexler's lists at $5-$10 each at grade, stuffed in drawers existing only as dead weight since there's no way of liquidating short of nickel and diming them out. I also have a number of original rolls somewhere displaying "best of" varieties on the ends, and very productive rolls at that, sitting for the same reason. If there is any present demand for the variety, I would try to get what I can out of it now unless youre okay coming to the point where you can barely give it away. The Wisconsin high/low leaf is simply in another world demand-wise than the great majority of more recent varieties, and is a different ballgame.
I got a piece of thin cardboard the same shape and almost thickness of a quarter in the middle of a roll. the possibilities are endless.